Research Interests

The BIG QUESTION in my research program is...

"How do proteins with similar structures carry out different functions?"

To answer this question, I use multiplexed assays of variant effects and protein evolution methods to create topographical maps of protein mutational space. By introducing all possible mutations to a protein, we can tell which sets of mutations change the protein's function. From there, we can determine if the protein's amino acid sequence results in it being a "generalist" or a "specialist".

I am particularly interested in applying these technologies to understand protein diversity and function in the blood coagulation system. These studies have the potential to lead to novel therapeutics, as well as unravel the mysteries of protein specificity and function.